Differential equations and Drug resistance


Drug Resistance Introduction

Drug resistance is when cancer cells resist treatment.

Required Reading

Drug resistance in cancer: Principles of emergence and prevention by Natalia L. Komarova and Dominik Wodarz (How drug resistance poses a problem to treatment)

Evolutionary dynamics of cancer in response to targeted combination therapy by Ivana Bozic, Johannes G Reiter, Benjamin Allen, Tibor Antal,
Krishnendu Chatterjee, Preya Shah, Yo Sup Moon, Amin Yaqubie, Nicole Kelly, Dung T Le, Evan J Lipson, Paul B Chapman, Luis A Diaz Jr, Bert Vogelstein & Martin A Nowak (Shows strategies of overcoming drug resistance)

Evolution of Resistance to Cancer Therapy by Franziska Michor, Martin A. Nowak1 & Yoh Iwasa (Shows how to estimate chances of cancer  treatment)

Angiogenesis Introduction

In cancer, angiogenesis is a process where the tumor obtains blood vessels to nourish itself.

Required Reading

Tumor Angiogenesis by Judah Folkman & Raghu Kalluri (A summary of angiogenesis)

The Role of the Tumor Microenvironment in Regulating Angiogenesis by Randolph S. Watnick (Shows how the tumor’s environment affects angiogenesis)

Angiogenesis and Tumor Metastasis by Bruce R. Zetter (Shows how angiogenesis helps the tumor spread to other parts of the body)

Apoptosis Introduction

Apoptosis is the process where damaged cells commit suicide to replace themselves with new cells. If damaged cells are not replaced then diseases, like cancer, can form.

Required Reading

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics by JF Kerr, AH Wyllie & AR Currie (The original research paper on apoptosis)

Developmental apoptosis in C. elegans by Guillaume Lettre and Michael O. Hengartner (A review on apoptosis in worms)

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells by David L. Vaux, Suzanne Cory & Jerry M. Adams (Connects failing apoptosis to cancer)